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Laser Therapy! The Technology Behind How It Works!

 

There have been numerous scientific studies and research articles that discuss different aspects of LLLT or Low Level Laser Therapy and LED biostimulation, each with their own unique perspective. The simplest explanation about how it works is this:

 

Photonic Energy (Light) produced by the laser or LED is absorbed by the skin and cells of the body, the Photonic Energy (Light) is converted into chemical energy which initiates a cascade of events at a cellular level. 

 

LLLT promotes healing in many conditions because it penetrates the skin, increases the ATP and activates enzymes in the targeted cells.

 

Growth factor response within the cells and tissue as a result of increased ATP and protein synthesis.

Improved cell proliferation

Pain relief as a result of increased endorphin release.

Strengthening the immune system response via increasing levels of lymphocyte activity.

Below we have links to the NASA Web site with research articles highlighting on their research into bio-photonic light stimulation:

 

Light emitting diodes bring relief to young cancer patients; NASA technology used for plant growth now in clinical trials

 

NASA Space Technology Shines Light on Healing - Photos

 

NASA Space Technology Shines Light on Healing - Videos

 

NASA Space Technology Shines Light on Healing - Story

 

Tissue regeneration via improved cellular function. To paraphrase NASA research:

 

Low-energy photon irradiation by light in the red to near-IR spectral range with low-energy lasers and LED's has been found to modulate various biological processes in cell culture and animal models. This phenomenon of photo-biomodulation has been applied clinically in the treatment of soft tissue injuries and the acceleration of wound healing. The mechanism of photo-biomodulation by red to near-IR light at the cellular level has been ascribed to the activation of mitochondria respiratory chain components, resulting in initiation of a signaling cascade that promotes cellular proliferation and cytoprotection.

 

A growing body of evidence suggests that cytochrome oxidase is a key photoacceptor of light in the red to near-IR spectral range. Cytochrome oxidase is an integral membrane protein that contains four redox active metal centers and has a strong absorbance in the red to near-IR spectral range detectable in vivo by near-IR spectroscopy.

 

Moreover, 630-680 nm of irradiation has been shown to increase electron transfer in purified cytochrome oxidase, increase mitochondria) respiration and ATP synthesis in isolated mitochondria, and up-regulate cytochrome oxidase activity in cultured neuronal cells.

 

Photostimulation induces a cascade of signaling events initiated by the initial absorption of light by cytochrome oxidase. These signaling events may include the activation of immediate early genes, transcription factors, cytochrome oxidase subunit gene expression, and a host of other enzymes and pathways related to increased oxidative metabolism.

 

In addition to increased oxidative metabolism, red to near-IR light stimulation of mitochondrial electron transfer is known to increase the generation of reactive oxygen species. These mitochondrially generated reactive oxygen species may function as signaling molecules to provide communication between mitochondria and the cytosol and nucleus.

 

Therapeutic photo-biomodulation for methanol-induced retinal toxicity.

 

Proceedings of the National Academy of Sciences USA. 2003 Mar 18;100(6):3439-44

 

Click here for more information on ATP synthesis and Laser Therapy

 

 

Photo-biomodulation and photo-biostimulation

 

When studying the biological effects of Lasers and LED's on cells and tissue, the words photo-biomodulation and photo-biostimulation is often used. It refers to the stimulation of cells and tissue to to increase the levels of energy being produced in order to increase the cells function. The goal in photo-biomodulation is to stimulate the cells energy producing centers called the mitochondria in order to increase their energy production thus improving their function, doing so without exceeding or exhausting the cell or tissues ability to function properly.

 

Optimum Wavelengths

 

Research supports 630nm - 640nm as the optimum wavelength for surface tissue stimulation.

 

Research supports 660nm - 680nm as the optimum wavelength for deeper tissue stimulation.

 

Research supports infrared 808nm - 880nm as the optimum wavelengths for the deepest penetration as the Photonic Energy passes through the skin and does not begin absorption until it reaches the deeper tissues.

 

 

 

 

Optimum Power

 

The biological law known as Arndt-Schultz states that weak stimuli excite physiological activity, moderately strong ones retard it and very strong ones arrest it. A statement from Boyd's Textbook of Pathology-Sixth Edition states that there are two types of tissue changes in inflammation. (1) Degenerative and (2) Proliferate. If the irritant is intense, the effect is degeneration and destruction. If mild it acts as a stimulant and the effect is proliferation.

 

Growth will either be impaired or enhanced, the result depending on the intensity of the irritant. At the center of the inflammatory area the action of the irritant is severe, so that degeneration predominates; at the periphery the action is mild, so that the tissue may be stimulated to proliferate this part of the inflammatory process is known as healing.

 

This highlights the major difference between therapeutic Low Level Lasers and LED's vs Surgical cutting lasers.

 

 

Disclaimer

 

We make no claims as to the use or effectiveness of our devices. The products on or throughout this site have not been evaluated by the United States Food and Drug Administration (FDA) and are not approved or intended to diagnose, treat, cure or prevent any disease.

 

The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any treatment.

 

You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, before using any device, or if you have or suspect you might have a health problem.

 

F&Q

Lasers vs LED's

What is the difference?

 

LED's Produce (non-coherent, monochromatic light; spontaneous emission)

 

LASER's Produce (coherent, monochromatic light, stimulated emission)

 

 

 

Tiina Karu (1998:   The Science of Low-Power Laser Therapy) states that "...the coherence of light is of no importance in low-power laser clinical effects" and "the primary difference between lasers and LED's is that the laser's coherent beam produces "speckles" of relatively high power density which can cause local heating of inhomogeneous tissues".

 

There is currently no doubt among researchers and scientists that the light emitted by LED's is effective in generating a biomodulatory response within living tissue, and therefore has a therapeutic role if used correctly.

 

The majority of published research on photo biomodulation has been conducted using LASER's and not LED's. It has only been in more recent years that LED's have been made with an high enough output power to be beneficial for photo biomodulation.

 

NASA has produced the best research documentation to date supporting the effectiveness of LED's to stimulate plants and human tissue through photo biomodulation. It is misleading however to misrepresent LED's by suggesting that meaningful information about practical LED therapy can be simply derived from LASER therapy research. Until more research is carried out on the effect of LED's on photo biomodulation, and the mechanisms of photo biomodulation are better understood, this will remain the case.

 

To summarize, it is sufficient to say that both LED's and LASER's work, but more research is constantly being carried out with LED's in order to determine their best suited role in photo-biomodulation.

 

There are a number of different parameters that can affect the outcome of irradiation, Especially when using more than 1 kind or type of stimulation method, i.e. (2 or more power densities, different wavelengths, coherent and non-coherent light, laser speckles, pulsing frequencies, etc.). It would be difficult for anyone to say that, at this stage in our understanding of photo biomodulation, they have determined the optimal combination of these numerous and variable parameters.

 

The debate over which is better, LASER or LED is currently unsettled, and the affect of each particular combination of wavelengths and output power has yet to be fully determined. There is much research pointing toward the best combination for depth of effect and the type of tissue that is affected but no particular combination can be truly labeled as optimal until the effects of every possible combination are fully understood.

 

Evidence of the effectiveness LASER vs LED is still being determined, until we gain a better understanding of the mechanisms by which each variable (e.g.. coherent vs non-coherent) affects the biological system in vitro and in vivo. Once we fully understand the individual mechanisms, we can look at combining these mechanisms to see how each combination affects the overall biomodulatory response, and how then to apply the various responses for optimal therapeutic benefit.

 

It will take time, and research funding is always hard to come by, but we are talking about a valid area of scientific investigation and most researches believe the results should be worth the effort.

 

 

 

Disclaimer

 

We make no claims as to the use or effectiveness of our devices. The products on or throughout this site have not been evaluated by the United States Food and Drug Administration (FDA) and are not approved or intended to diagnose, treat, cure or prevent any disease.

 

The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any treatment.

 

You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, before using any device, or if you have or suspect you might have a health problem.

The Life Line Laser - Laser Products

We have produced 2 Standard laser models based on the continuous mode lasers and commonly produce custom laser models to meet special stimulation requirements. All of our lasers are produced and designed for experimentation only and are not intended to diagnose, treat, cure, or prevent any disease.

        

                                                                                            Our current models Include:

635nm 5mW Class IIIa for
Surface Stimulation
Starting at $600 depending on configuration.

660nm 25mW Class IIIb for
Deeper Tissues
Starting at $650 depending on configuration.


Custom Versions are available upon request which can include multiple Laser Diodes, Infrared Diodes, and Laser and LEDs Together. Please call for details.

The Life Line Laser - LED Products

Introducing our new line of Alura LED Stimulators based on the 395nm - 435nm Blue and 635nm - 680nm wavelengths.

They are small to medium sized and portable. Each unit will be capable of lasting for 50-100 hours on a single set of batteries depending on the configuration. Each LED is capable of lasting up to 100,000 hours before needing replacement.

The enhanced power chips in our LED Stimulators are capable of providing a total output of 50mW - 500mW of optical output power depending on the configuration.

Our Current Models Include:

Alura 3635
635nm 50mw LED Stimulator
$239.00

Alura 3435
435nm 50mw LED Stimulator
$239.00

Discounts are available for purchases of 4 or more units.

More models are still in development and custom configurations are available to suit your needs. Please call for details.

Please refer to the LED vs Laser section for more details on the differences between these 2 modalities.

All of our LED Stimulators are produced and designed for experimentation only and are not intended to diagnose, treat, cure, or prevent any disease.